Naomi Osaka’s clash with Elina Svitolina kicks off a day of tantalising match-ups that will finalise the Australian Open semi-final line-ups on Wednesday..

The Japanese world No.4 and sixth-seeded Ukranian Svitolina are first up at Rod Laver Arena on Wednesday with Osaka out to build on her breakthrough US Open triumph last year.

A victory would put the 21-year-old on course for a semi-final rematch of her controversial showdown with Serena Williams in the Flushing Meadows decider.

Williams, who had a meltdown at a chair umpire in that match, is set to face towering Czech Karolina Pliskova in Wednesday’s early-afternoon clash.

Two-time Wimbledon champion Petra Kvitova and unheralded American Danielle Collins will meet in the other semi-final on Thursday.

Kvitova vanquished Australian hope Ashleigh Barty in straight sets on Tuesday night, while Collins downed Russia’s Anastasia Pavlyuchenkova.

Florida native Collins continued her dream run in her first main-draw appearance at Melbourne Park, having never won a game at a major prior to the tournament.

Big-serving Canadian Milos Raonic’s quarter-final clash with Frenchman Lucas Pouille kicks off the men’s action on Wednesday.

The winner will face either Serbian top seed Novak Djokovic or Japan’s Kei Nishikori, who will face off in the night session on Rod Laver Arena.

Gunning for a seventh Australian Open crown, Djokovic will be hoping to capitalise on marathon man Nishikori having spent almost 14 hours on court in a gruelling run to the final eight.

Rafael Nadal on Tuesday night dismantled rising American Frances Tiafoe to set up a semi-final meeting with Greek prodigy Stefanos Tsitsipas.