State Farm Stadium will play host to Tuesday's Round 13 NFL game between Buffalo Bills and San Francisco 49ers. The game kicks off at 12:16 pm with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Buffalo Bills vs. San Francisco 49ers game and give you our free tips and bets.

When: Tuesday December 8, 2020 at 12:16 pm

Where: State Farm Stadium

Bet 💰: Bet On This Match HERE

Buffalo Bills vs San Francisco 49ers Odds

Buffalo Bills vs San Francisco 49ers Preview

The 5-6 San Francisco 49ers are clinging to post-season hopes despite sitting last in the NFC West. With Jimmy Garoppolo still sidelined, last year’s Super Bowl runners-up arrested a three-match slide with a gritty 23-20 victory over the in-form Rams.

The injury-hit 49ers are also exiled from their home for the time being due to COVID-19 restrictions, forced to play out of Phoenix.

The 8-3 Buffalo Bills, meanwhile, are on track for their first AFC East title since 1995. They have won three of their last four, coming out of the bye with a 27-17 win over the Chargers. The next fortnight against the 49ers and Steelers could have a major bearing on their campaign.

Josh Allen left early with an ankle complaint but the breakout QB is on course to take the field this week – and lead the Bills to MNF success.

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Buffalo Bills vs San Francisco 49ers Tip