Fremantle have lost star duo Nat Fyfe and Aaron Sandilands to injury as Brisbane overcame their opening-quarter demons to post a 55-point AFL win at Optus Stadium.

Sandilands succumbed to a right calf injury just minutes before the opening bounce on Sunday, while Fyfe injured his right hamstring midway through the second term.

Brisbane made the most of the injuries by running rampant in the 18.11 (119) to 9.10 (64) win, stunning the 41,674-strong crowd.

Lions ruckman Stefan Martin dominated in the absence of Sandilands, finishing the match with 46 hitouts, 19 disposals and seven clearances in his 150-game milestone.

Dayne Beams tallied 33 disposals and 12 clearances and Lewis Taylor booted three goals.

The Lions entered the match having lost all 13 of their opening quarters this year.

But they ended that rut with the opening four goals of the game.

Fyfe struggled to assert his influence on the match opposed to tagger Jarrod Berry.

The Fremantle skipper received some treatment on his hamstrings early in the match and ended the first quarter with just five disposals and one clearance.

Fyfe tallied just three more disposals in the second term before pinging his right hamstring while leaning forward to collect the ball on the wing.

Brisbane led by 24 points as Fyfe limped his way to the bench and the visitors entered the long break with the same advantage.

Martin dominating in the ruck, the Lions put Fremantle to the sword in the third quarter, booting six of the first seven goals of the stanza to open up a 54-point lead.

The Lions’ second win of the season lifts them one game clear of last-placed Carlton.

The cellar-dwellers lock horns at the Gabba next Saturday in a match that will go a long way towards deciding the wooden-spoon battle.

Fremantle’s shock loss leaves them two wins and a significant percentage adrift of eighth spot.

The Dockers lacked intent and urgency against the Lions and ended up losing the contested possession count 141-122.

It was in stark contrast with their two games before the bye, when they beat Adelaide and Carlton.