Port Adelaide co-captains Tom Jonas and Ollie Wines have been ruled out of the Power side to play the Crows in a savage double blow ahead of Showdown 46.
Jonas (calf) and Wines (broken ankle) were scratched after injuries over the past fortnight.
Wines pulled up sore after Friday night’s loss to Collingwood, and scans revealed he has sustained a small fracture in his fibula.
The 24-year-old is expected to return shortly after the mid-season bye.
Jonas has been unable to recover from a calf strain he suffered in the lead up to the ANZAC round game against North Melbourne.
Brad Ebert will also miss the match due to the concussion he suffered against Collingwood.
With vice captain Hamish Hartlett also sidelined with a hamstring injury, and Robbie Gray out with a broken hand, Port have no dedicated leader for the clash.