Bills Stadium will play host to Monday's Round 11 NFL game between Indianapolis Colts and Buffalo Bills. The game kicks off at 5:01 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Indianapolis Colts vs. Buffalo Bills game and give you our free tips and bets.

When: Monday November 22, 2021 at 5:01 am

Where: Bills Stadium

Bet 💰: Bet On This Match HERE

Indianapolis Colts vs Buffalo Bills Odds

Indianapolis Colts vs Buffalo Bills Preview

This is a sneaky big game in terms of the AFC playoff picture with both teams in a position where they can’t afford to drop it.

It is shaping up as a huge test for Colts running back Jonathan Taylor who has rushed for over 100 yards in all five of Indy’s victories in the last seven weeks.

While Buffalo has one of the league’s best overall defensive units, I still like Taylor to shoulder a big load and keep the Colts moving up and down the field.

It’s the other side of the ball which is why I am staying away from the Colts to cause an upset.

Their defence has been very poor of late and this could turn into a very entertaining shootout, even with the inclement weather forecast.

Content provided by Ladbrokes

Indianapolis Colts vs Buffalo Bills Tip