State Farm Stadium will play host to Monday's NFL game between San Francisco 49ers and Arizona Cardinals. The game kicks off at 7:26 am with Arizona Cardinals heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the San Francisco 49ers vs. Arizona Cardinals game and give you our free tips and bets.

When: Monday October 11, 2021 at 7:26 am

Where: State Farm Stadium

Bet 💰: Bet On This Match HERE

San Francisco 49ers vs Arizona Cardinals Odds

San Francisco 49ers vs Arizona Cardinals Preview

The NFL’s last undefeated team, the Arizona Cardinals, returns home with the NFL’s most explosive offence and a defence that ranks in the top 10 in points allowed.

That ranking could improve against a 49ers team that will likely turn to rookie Trey Lance with Jimmy Garoppolo battling a calf injury.

Lance flashed against Seattle last week throwing two touchdowns but was put under plenty of pressure and the Cardinals pass rush will be looking to tee off on him here.

Kyle Shanahan will have to scheme around what should be some pretty heavy pressure and hope that his depleted running back group can get the job done.

Hope is all well and good but the performances speak for themselves and I’ll back the Cardinals to put together another impressive win.

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San Francisco 49ers vs Arizona Cardinals Tip