TIAA Bank Field will play host to Monday's Round 11 NFL game between San Francisco 49ers and Jacksonville Jaguars. The game kicks off at 5:01 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the San Francisco 49ers vs. Jacksonville Jaguars game and give you our free tips and bets.

When: Monday November 22, 2021 at 5:01 am

Where: TIAA Bank Field

Bet 💰: Bet On This Match HERE

San Francisco 49ers vs Jacksonville Jaguars Odds

San Francisco 49ers vs Jacksonville Jaguars Preview

This has the makings of a surprisingly tough spot for the 49ers coming off a Monday night game and hopping on a cross-country flight for an early kickoff.

After recording their biggest win of the season, they will deal with a scrappy Jaguars team that does not go away, even if they are still largely talent deficient across the board.

The 49ers got their offence going against the LA Rams and if Kyle Shanahan can get his team refocused they will be able to take care of business here.

With the line at -6 at the time of writing, the potential for a Jaguars back door cover is very high so for that reason I’ll back the 49ers in a close one.

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San Francisco 49ers vs Jacksonville Jaguars Tip