Spanish 10th seed Roberto Bautista Agut was upset 3-6 6-1 6-4 3-6 6-3 by Kazakhstan’s Mikhail Kukushkin in the first round of the US Open on Tuesday.
Bautista Augut, who reached the semi-finals at Wimbledon last month, was broken seven times by Kukushkin as he exited the year’s final grand slam in the opening round for the second consecutive year.
It was Kukushkin’s first victory over the Spaniard in four career meetings.
Up next for the Kazakh will be Australia’s Alexei Popyrin, who beat Argentine Federico Delbonis 6-1 7-5 7-6(5) earlier on Tuesday.
Big-serving American John Isner beat Spain’s Guillermo Garcia-Lopez 6-3 6-4 6-4.
The 14th seed sent down 29 aces, hit 55 winners, won 20 of 26 points at the net and saved the only break point he faced to ease into the second round.
Italy’s Matteo Berrettini beat Frenchman Richard Gasquet 6-4 6-3 2-6 6-2 to advance to the US Open second round for the first time in his career.
The 23-year-old fired 18 aces in beating his veteran opponent in two hours and 43 minutes and now faces Australian Jordan Thompson, who scored a brilliant win over Joao Sousa 6-3 6-2 6-4.
American John Isner, the 14th seed, beat Spain’s Guillermo Garcia-Lopez in straight sets.