Ana Ivanovic handed Maria Sharapova her first loss of the claycourt tennis season as she beat the Russian eighth seed 6-1 6-4 on Thursday to reach the quarter-finals of the ATP-WTA Rome Masters.
Sharapova had won back-to-back titles in Stuttgart and Madrid, compiling a dozen straight victories.
Ivanovic, the 2008 Roland Garros winner and world number one, had won just two of ten previous meetings with the four-time grand slam champion, the last seven years ago at a Roland Garros semi-final.
The Serb next plays Spain’s Carla Suarez Navarro.
Earlier, Chinese second seed Li Na defeated Samantha Stosur 6-3 6-1.
Stosur, a 2010 Roland Garros finalist, had beaten world No.2 Li in all six of their previous meetings going back to 2007.
The victory was her second straight over an Australian opponent after defeating qualifier Casey Dellacqua in the previous round.
But China’s top female athlete made inroads against Stosur’s one-way scoreline with her first victory, achieved in 68 minutes with five breaks of the 30-year-old Stosur.
“In the last six matches I tried to control the ball, but she was able to get a lot of chances,” said 32-year-old Li.
Li will play a quarter-final against Italian 10th seed Sara Errani, who beat Czech Petra Cetkovska 6-3 7-6 (7-3).
Li finished Rome runner-up in 2012, holding a match point against eventual champion Maria Sharapova.
Australian Open champion Li is looking for her third trophy of the season as she prepares for the French Open, which she won in 2011.
Men’s third-seeded Monte Carlo winner Stanislas Wawrinka joined fellow Swiss Roger Federer on the Rome scrapheap after a 5-7 6-2 6-3 second round loss to German 15th seed Tommy Haas.
The 36-year-old has now won both of his matches with Wawrinka, a 2008 finalist at the Foro Italico.
Haas ended with seven aces to eight for Wawrinka, who could not hold onto leads throughout the two-hour contest.
The German produced 32 winners while Wawrinka struck 40 unforced errors.
Haas broke in the third set for 5-3, then finished with an ace a game later on his first match point.