Alexander Zverev has made another week one exit from the US Open after a four-sets loss to Philipp Kohlschreiber in all-German third round match.

The fourth seed won the first set tiebreaker but veteran Kohlschreiber proved too consistent from that point on and prevailed 6-7 (1-7) 6-4 6-1 6-3 in three hours and nine minutes.

The 21-year-old Zverev is considered a rising star of men’s tennis and has won three Masters titles in his career and leads the tour with 45 wins this season.

However, he has only one grand slam quarter-final appearance to his credit, at this year’s French Open, and he’s now 4-4 at Flushing Meadows.

Kohlschreiber advanced to the last 16 at the event for the fifth time and will meet Kei Nishikori or Diego Schwartman for a place in the quarter-finals.

Meanwhile, Joao Sousa won three tiebreakers in his 7-6 (7-5) 4-6 7-6 (7-4) 7-6 (7-5) victory over 17th-seeded Frenchman Lucas Pouille.

The unseeded Portuguese will play Novak Djokovic or Richard Gasquet in his maiden fourth-round appearance at a major.

Earlier, Roger Federer’s 51 winners included a jaw-dropping flick around the net post as he swept aside Nick Kyrgios 6-4 6-1 7-5 to reach the fourth round in a 17th consecutive appearance in New York.

There he will face 55th-ranked John Millman after the Australian defeated Mikhail Kukushkin 6-4 4-6 6-1 6-3, to seal his first appearance in a grand slam second week.